SUPRACAL K2

Supracal K2 is a unique combination of Calcium, Vitamin D3, and Vitamin K2 along with Magnesium and Zinc. Supracal K2 helps in adequate utilization of calcium in bone and heart. Inadequate levels of calcium can cause decreased bone mineral density, which can cause an increase in the risk of bone fractures. Supplemental calcium helps promote bone mineral density and can prevent osteoporosis.

But, an elevated consumption of calcium may raise the risk for heart disease and cause calcium deposits in blood-vessel walls and soft tissues. Vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening.

BENEFITS

• Supports in osteoporosis patients with Cardiovascular disease risk
• Helps in senile osteoporosis
• Helps in osteoporotic fractures

Dedicated name of product

Supracal K2 tablet

Generic name

Calcium citrate, vitamin K2, Vitamin D3, Magnesium

Indication & usage

• Helps bone health
• Osteoporosis
• Steroid-induced bone loss
• Osteopenia

Composition

Each film coated tablet contains: Calcium citrate 1000 mg, equivalent to elemental Calcium 210.76 mg, Vitamin K2 45 mcg, Vitamin D3 200 IU, Zinc sulphate monohydrate equivalent to elemental Zinc 4 mg, Magnesium hydroxide equivalent to elemental Magnesium 100 mg.

Pharmacology and pharmacokinetics functions of the product

Supracal K2 is a unique combination of vitamins and minerals, which help in maintaining bone architecture and health. Aberrant calcium metabolism can lead to disorders such as osteoporosis and cardiovascular disease.

Calcium is an essential mineral required for the development and maintenance of bone and teeth. Vitamin D3 is a fat-soluble sterol, aids in the regulation of calcium and phosphate homeostasis, and bone mineralization. Its activated form promotes absorption of calcium from the intestine, decreases the excretion of calcium and maintains calcium homeostasis. Vitamin K2 augments calcium utilization and regulates calcium level in the body. Insufficient vitamin K2 leads to decreased bone mineral density, a key factor in osteoporosis, and an excess of calcium in the arterial wall, which increases the risk of heart disease. Vitamin K2 appears to be a co-factor with Vitamin D4 and together they are a much more potent force to mineralize bone and amazingly de-mineralize soft tissue. Zinc is a trace element, form an essential part of many enzymes, and play a key role in protein synthesis and in cell division. Magnesium is important for the normal functioning of cells, nerves, muscles and bones.

Dosage and administration

One to two tablets daily or as directed by the physician. Swallow with a glass of water. Not to be chewed. Do not exceed the recommended dose.

Contraindications

Patients with hypercalcemia, hypercalciuria, nephrolithiasis. hypervitaminosis D and hypophosphatemia.

Side effects

Constipation, flatulence, nausea, abdominal pain and diarrhea, pruritis, rash and urticaria.

Interactions

• May affect the absorption of tetracycline when used together
• Concurrent use with systemic corticosteroids may reduce calcium absorption
• Thiazide diuretics may decrease urinary excretion of calcium
• Concurrent use with ion-exchange resins may reduce gastrointestinal (GI) absorption of vitamin D
• Hypercalcemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels
• Bisphosphonate or sodium fluoride should be given at least 3 hr. before calcium containing preparations
• Lowers warfarin efficacy if used concurrently

Warning & Precautions

• Increased risk of hypercalcemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D
• Caution when using in patients with history of kidney stones
• Renal impairment: frequent monitoring of serum calcium and phosphorus is recommended

Usage in pregnancy & lactation

Calcium is safe when used in recommended doses during pregnancy and breast-feeding. Please consult your physician before administration.

Packaging information

Blister packs of 2×15’s tablets.

Condition for preservation and storage

Store below 30⁰ C, protect from moisture.

Producing country name

Iran

Manufacturing company name

Manufactured By: Perarin Pars Laboratory
Trademark & IRC Holder : Abba Darou Teb